NIST Cybersecurity Framework
Aligned Asset Risk Management Across IT, OT, and IoT.

Sepio’s NIST Cybersecurity Framework solution delivers complete visibility, real-time risk management, and regulatory compliance across IT, OT, and IoT environments. Empower your organization to secure all connected devices and maintain business continuity.

NIST Cybersecurity Framework Overview

In response to a U.S. Executive Order to enhance critical infrastructure cybersecurity, the National Institute of Standards and Technology (NIST) developed the Cybersecurity Framework (CSF). Addressing the lack of uniform standards, the CSF provides organizations with proven best practices to enhance security and resilience. Consisting of five core functions—Identify, Protect, Detect, Respond, and Recover—the Cybersecurity Framework (CSF) offers a set of standards, recommendations, and guidelines to help enterprises identify and detect attacks, respond effectively, and recover from incidents.

Developed in collaboration with leading cybersecurity experts and critical infrastructure operators worldwide, the NIST Cybersecurity Framework (CSF) is widely recognized as one of the most trusted foundations for building a strong cybersecurity program. By adopting the NIST Cybersecurity Framework (CSF), enterprises can eliminate gaps in their cybersecurity strategy, strengthen supply chain security, and ensure consistent protection across their digital ecosystem.
NIST Cybersecurity Framework

Physical Layer Visibility and NIST CSF

Traditional, traffic-based security solutions fail to cover the Physical Layer (Layer 1), resulting in inaccurate asset inventories, unaccounted-for vulnerabilities, and unidentified risks—all of which hinder cybersecurity efforts. This lack of visibility limits alignment with the NIST Cybersecurity Framework (CSF), as many required controls cannot be met. As a result, organizations experience weakened cybersecurity and resilience capabilities, increasing overall business risk.

Sepio’s Trafficless Network Security Solution provides full asset visibility without relying on traffic inspection. Unlike legacy solutions, it identifies and secures all hardware assets without analyzing network traffic or installing extra sensors—maintaining performance, resilience, and privacy.

NIST Solution

How Sepio Enables Cybersecurity Compliance

Sepio’s solution provides comprehensive asset visibility, helping enterprises fulfill many NIST Cybersecurity Framework (CSF) controls—from Identify to Respond. By leveraging physical-layer data, Sepio accurately detects and identifies all IT, OT, and IoT assets across USB and network interfaces, including managed, unmanaged, and hidden devices.

This advanced visibility enables organizations to:

  • Achieve complete asset discovery and continuous monitoring
  • Make informed, risk-based security decisions
  • Enforce stronger access and usage controls
  • Detect incidents faster
  • Respond to and mitigate threats effectively
  • Generate comprehensive incident reports
  • …and much more.
NIST Cybersecurity Framework - Fulfilling Cybersecurity Controls

Fulfilling Cybersecurity Controls with Sepio’s NIST Solution

With Sepio, organizations gain full visibility and control over IT, OT, and IoT assets, turning the NIST Cybersecurity Framework into actionable protection against cyber risks—Identify, Protect, Detect, and Respond in real time.

  • Identify: Sepio detects and identifies all IT, OT, and IoT assets and devices. Using multiple Layer 1 parameters and machine learning, it detects any device—managed, unmanaged, or hidden. Sepio’s solution provides 100% asset visibility and complete cybersecurity asset risk management (ARM).
  • Protect: Sepio supports risk scoring for vulnerable devices to strengthen risk management and ensure uninterrupted delivery of critical infrastructure services. Leveraging Hardware Access Control (HAC) and Zero Trust Hardware Access (ZTHA), the platform enhances and automates policy enforcement, preventing unauthorized devices from accessing or disrupting operations.
  • Detect: Sepio identifies anomalies in device IDs and digital fingerprints in real time. It detects malicious, rogue, or policy-violating devices, ensuring that threats are recognized immediately.
  • Respond: Organizations gain full visibility into all assets and can effectively manage cyber asset risk by applying NIST Cybersecurity Framework control measures upon detecting an event.

Build a Resilient Cybersecurity Foundation with Sepio

With complete physical-layer visibility, organizations can close critical security gaps, improve regulatory compliance, and strengthen their overall cybersecurity posture. By gaining full insight into every connected device, security teams can proactively manage risk, prevent unauthorized access, and respond swiftly to emerging threats.

Sepio helps organizations move beyond traditional security limitations, delivering the transparency, control, and confidence needed to protect today’s complex digital environments. Our solution enables alignment with the NIST Cybersecurity Framework (CSF), reduces operational risk, and ensures continuous business operations across IT, OT, and IoT ecosystems.
By integrating Sepio into your cybersecurity strategy, you gain a scalable, future-ready foundation that supports compliance, resilience, and long-term security maturity—empowering your organization to stay secure, compliant, and prepared for tomorrow’s threats.

Take Control of Your Network Assets.

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